西沙必利对新生儿QTc间期的影响。
Effects of cisapride on QTc interval in neonates.
作者信息
Bernardini S, Semama D S, Huet F, Sgro C, Gouyon J B
机构信息
Centre Hospitalier Universitaire, Dijon, France.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1997 Nov;77(3):F241-3. doi: 10.1136/fn.77.3.f241.
Abstract
AIM
Prospective survey of the effects of cisapride on QTc interval in neonates given cisapride.
METHODS
QTc interval was determined just before and 2.9 (0.9) days after outset of the treatment in 49 neonates treated with cisapride between 1 August 1995 and 29 February 1996.
RESULTS
Cisapride significantly increased QTc interval (p = 0.0001), and this was higher when birthweight or gestational age were lower. The prolongation of QTc interval above the arbitrary value of 0.450 (n = 7) was clinically asymptomatic and was significantly more common in the infants born with a gestational age < or = 33 weeks (n = 6).
CONCLUSION
The findings indicate that cisapride accumulates in less mature neonates. Further pharmacokinetic studies are needed.
摘要
目的
前瞻性调查西沙必利对接受西沙必利治疗的新生儿QTc间期的影响。
方法
在1995年8月1日至1996年2月29日期间，对49例接受西沙必利治疗的新生儿在治疗开始前及开始后2.9（0.9）天测定QTc间期。
结果
西沙必利显著增加QTc间期（p = 0.0001），出生体重或胎龄越低，QTc间期增加越明显。QTc间期延长超过任意设定值0.450（n = 7）的情况在临床上无症状，且在胎龄≤33周出生的婴儿中显著更常见（n = 6）。
结论
研究结果表明西沙必利在成熟度较低的新生儿中蓄积。需要进一步进行药代动力学研究。
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