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神经毒性作为神经退行性疾病的一种机制:基础与临床方面

Neurotoxicity as a mechanism for neurodegenerative disorders: basic and clinical aspects.

作者信息

Danysz W

机构信息

Preclinical R & D, Merz & Co., Frankfurt am Main, Germany.

出版信息

Expert Opin Investig Drugs. 2001 May;10(5):985-9. doi: 10.1517/13543784.10.5.985.

Abstract

This three day meeting focused on chronic neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and amylotrophic lateral sclerosis (ALS). It attracted 69 participants from 10 countries with dominance of Chile and USA. Neurodegeneration and its prevention increasingly gain in importance as the number of people affected increases year-by-year. The meeting addressed various basic aspects having pragmatic implications such as: oxidative stress, inflammatory reaction, glial activation, role of glutamatergic system and apoptosis using a plethora of in vitro and in vivo methods.

摘要

这次为期三天的会议聚焦于慢性神经退行性疾病,如帕金森病(PD)、阿尔茨海默病(AD)和肌萎缩侧索硬化症(ALS)。它吸引了来自10个国家的69名参与者,其中以智利和美国为主。随着受影响人数逐年增加,神经退行性变及其预防变得越来越重要。会议使用大量体外和体内方法探讨了各种具有实际意义的基础方面,如氧化应激、炎症反应、胶质细胞活化、谷氨酸能系统的作用和细胞凋亡。

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