Kaigler D, Mooney D
Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor 48109-1078, USA.
J Dent Educ. 2001 May;65(5):456-62.
Tissue engineering is a novel and exciting field that aims to re-create functional, healthy tissues and organs in order to replace diseased, dying, or dead tissues. The field has developed due to the inadequate supply of organs and tissues for patients requiring organ and tissue replacement. The following review first describes three major tissue engineering strategies. Although similar in their objectives, these strategies each maintain a unique component. Next, several examples of preclinical and clinical progress engineering oral-maxillofacial tissues are presented. Each of these examples highlights specific tissue engineering applications to different tissues of the oral-maxillofacial apparatus. Finally, practical implications are addressed as well as challenges that must be met in order for tissue engineering to reach its full potential.
组织工程是一个新颖且令人兴奋的领域,其旨在重新创建功能性的健康组织和器官,以替代患病、濒死或坏死的组织。由于需要器官和组织置换的患者可用的器官和组织供应不足,该领域得以发展。以下综述首先描述三种主要的组织工程策略。尽管这些策略目标相似,但每种策略都有其独特的组成部分。接下来,介绍了口腔颌面组织工程临床前和临床进展的几个实例。每个实例都突出了针对口腔颌面器官不同组织的特定组织工程应用。最后,阐述了实际意义以及组织工程要充分发挥其潜力必须应对的挑战。