Gaihre Bipin, Uswatta Suren, Jayasuriya Ambalangodage C
Department of Bioengineering, College of Engineering, University of Toledo, Toledo, OH 43607, USA.
Department of Orthopedic Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.
J Funct Biomater. 2017 Nov 20;8(4):49. doi: 10.3390/jfb8040049.
Engineering craniofacial bone tissues is challenging due to their complex structures. Current standard autografts and allografts have many drawbacks for craniofacial bone tissue reconstruction; including donor site morbidity and the ability to reinstate the aesthetic characteristics of the host tissue. To overcome these problems; tissue engineering and regenerative medicine strategies have been developed as a potential way to reconstruct damaged bone tissue. Different types of new biomaterials; including natural polymers; synthetic polymers and bioceramics; have emerged to treat these damaged craniofacial bone tissues in the form of injectable and non-injectable scaffolds; which are examined in this review. Injectable scaffolds can be considered a better approach to craniofacial tissue engineering as they can be inserted with minimally invasive surgery; thus protecting the aesthetic characteristics. In this review; we also focus on recent research innovations with different types of stem-cell sources harvested from oral tissue and growth factors used to develop craniofacial bone tissue-engineering strategies.
由于颅面骨组织结构复杂，工程化构建颅面骨组织具有挑战性。当前用于颅面骨组织重建的标准自体骨移植和异体骨移植存在诸多缺点，包括供区并发症以及恢复宿主组织美学特征的能力。为克服这些问题，组织工程和再生医学策略已被开发出来，作为重建受损骨组织的一种潜在方法。不同类型的新型生物材料，包括天然聚合物、合成聚合物和生物陶瓷，已以可注射和不可注射支架的形式出现，用于治疗这些受损的颅面骨组织，本文将对其进行综述。可注射支架可被视为颅面组织工程的一种更好方法，因为它们可以通过微创手术插入，从而保护美学特征。在本文中，我们还将重点关注从口腔组织中获取的不同类型干细胞来源以及用于制定颅面骨组织工程策略的生长因子的最新研究创新。
