Bushnell P J, Shelton S E, Bowman R E
Bull Environ Contam Toxicol. 1979 Aug;22(6):819-26. doi: 10.1007/BF02027031.
Rhesus monkeys were exposed to lead (Pb) acetate under various regimens during the first 12 months of life. At 30 months of age, these animals and unexposed controls were confined to an unfamiliar experimental chamber for one week. Serum cortisol concentration and Pb concentration in whole blood (PbB) were measured prior to, during, and after this confinement. Cortisol concentrations rose 60--90% within 2 hours of confinement, and declined to baseline levels after 98 hours of confinement. Mean baseline PbB levels reflected the state of clearance of the previously-ingested lead, rose 25--35% within 2 hours of confinement, and reached mean maximum levels as much as 100% above baseline after 98 hours of confinement. The data are discussed in terms of hormonal mobilization of Pb stored in bone, and subgest (1) that this storage is multicompartmental, (2) that more than one process is probably involved in its mobilization, (3) that cortisol probably does not directly affect PbB levels, and (4) that stress should be considered a potential factor in determining the PbB in studies of Pb metabolism.
恒河猴在出生后的前12个月内，按照不同的方案接触醋酸铅。在30个月大时，将这些动物和未接触过铅的对照动物置于一个陌生的实验室内一周。在禁闭前、禁闭期间和禁闭后测量血清皮质醇浓度和全血铅浓度（PbB）。禁闭2小时内，皮质醇浓度升高60%-90%，禁闭98小时后降至基线水平。平均基线PbB水平反映了先前摄入铅的清除状态，禁闭2小时内升高25%-35%，禁闭98小时后达到比基线水平高出多达100%的平均最高水平。从储存在骨骼中的铅的激素动员角度对数据进行了讨论，并提出以下假设：（1）这种储存是多室的；（2）其动员可能涉及多个过程；（3）皮质醇可能不会直接影响PbB水平；（4）在铅代谢研究中，应将应激视为决定PbB的一个潜在因素。
