Shivanyuk A, Rebek J
The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, MB-26, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7662-5. doi: 10.1073/pnas.141226898. Epub 2001 Jun 26.
Encapsulation complexes are assemblies in which a reversibly formed host more or less completely surrounds guest molecules. Host structures held together by hydrogen bonds have lifetimes in organic solvents of milliseconds to hours, long enough to directly observe the encapsulated guest by NMR spectroscopy. We describe here the action of alkyl ammonium compounds as guests that gather up to six molecules of the host module to form encapsulation complexes. The stoichiometry of the complexes--the largest hydrogen-bonded host capsules to date--is determined by the size and concentration of the guest.
包封复合物是一种组装体，其中可逆形成的主体或多或少完全包围客体分子。通过氢键结合在一起的主体结构在有机溶剂中的寿命为几毫秒至几小时，足够长以便通过核磁共振光谱法直接观察被包封的客体。我们在此描述烷基铵化合物作为客体的作用，它们聚集多达六个主体模块分子以形成包封复合物。这些复合物的化学计量比——迄今为止最大的氢键结合主体胶囊——由客体的大小和浓度决定。
