Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach.
作者信息
Meloni M M, Taddei M
机构信息
Dipartimento di Chimica, Università degli Studi di Sassari, Via Vienna 2, I-07100 Sassari, Italy.
出版信息
Org Lett. 2001 Feb 8;3(3):337-40. doi: 10.1021/ol006779z.
PMID:11428008
Abstract
[figure: see text] beta-Lactams were prepared on solid phase starting from serine, threonine, or other beta-hydroxyacids derived from naturally occurring amino acids and a resin bound hydroxylamine. The ring closure was carried out under Mitsunobu conditions. The amino group present on the beta-lactam was used to assemble a short peptide. After a reductive cleavage with Sml2, beta-lactam-containing peptides were obtained.
摘要
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