Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA 02138, USA.
Org Biomol Chem. 2018 Oct 3;16(38):6840-6852. doi: 10.1039/c8ob01833b.
During the past century, β-lactams have been identified as the core of penicillin and since then several strategies have been developed for their synthesis. Traditional methods for β-lactam synthesis usually involved amide bond formation and the Staudinger reaction. In recent years, by the advancement of photo- and transition metal-catalysis, several new methods have been reported for β-lactam synthesis. For instance: ligand assisted metal catalyzed C-H activation/intermolecular oxidative amidation draws attention for β-lactam synthesis. In this review we introduce methods for β-lactam synthesis and present newly developed reactions. We approach the synthesis of β-lactams according to different retro synthesis strategies.
在过去的一个世纪中，β-内酰胺已被确定为青霉素的核心，此后，人们已经开发了几种用于其合成的策略。β-内酰胺合成的传统方法通常涉及酰胺键形成和 Staudinger 反应。近年来，通过光和过渡金属催化的进步，已经报道了几种用于β-内酰胺合成的新方法。例如：配体辅助的金属催化 C-H 活化/分子间氧化酰胺化引起了人们对β-内酰胺合成的关注。在这篇综述中，我们介绍了β-内酰胺的合成方法，并展示了新开发的反应。我们根据不同的反合成策略来探讨β-内酰胺的合成。
