共刺激分子ICOS在实验性自身免疫性脑脊髓炎的免疫发病机制中起重要作用。
The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE.
作者信息
Rottman J B, Smith T, Tonra J R, Ganley K, Bloom T, Silva R, Pierce B, Gutierrez-Ramos J C, Ozkaynak E, Coyle A J
机构信息
Millennium Pharmaceuticals, 640 Memorial Drive, Cambridge, MA 02139, USA.
出版信息
Nat Immunol. 2001 Jul;2(7):605-11. doi: 10.1038/89750.
The inducible costimulatory molecule (ICOS) is expressed on activated T cells and participates in a variety of important immunoregulatory functions. After the induction of experimental allergic encephalomyelitis in SJL mice with proteolipid protein (PLP), brain ICOS mRNA and protein were up-regulated on infiltrating CD3+ T cells before disease onset. ICOS blockade during the efferent immune response (9-20 days after immunization) abrogated disease, but blockade during antigen priming (1-10 days after immunization) exacerbated disease. Upon culture with PLP and compared with immunized controls, splenocytes produced either decreased interferon-gamma (IFN-gamma, in efferent blockade) or excessive IFN-gamma (in priming blockade). PLP-specific immunoglobulin G1 was decreased in animals treated with anti-ICOS during antigen priming, but not in other groups.
诱导性共刺激分子（ICOS）在活化的T细胞上表达，并参与多种重要的免疫调节功能。在用蛋白脂蛋白（PLP）诱导SJL小鼠发生实验性变应性脑脊髓炎后，在疾病发作前，浸润的CD3+ T细胞上脑ICOS mRNA和蛋白上调。在传出免疫反应期间（免疫后9 - 20天）阻断ICOS可消除疾病，但在抗原致敏期间（免疫后1 - 10天）阻断ICOS会加重疾病。与PLP一起培养时，与免疫对照组相比，脾细胞产生的干扰素-γ（IFN-γ，在传出阻断中）减少或产生过量的IFN-γ（在致敏阻断中）。在抗原致敏期间用抗ICOS治疗的动物中，PLP特异性免疫球蛋白G1减少，但在其他组中未减少。
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