Mesityllithium as a reagent for chemoselective halogen-lithium exchange reaction.
作者信息
Kondo Y, Asai M, Miura T, Uchiyama M, Sakamoto T
机构信息
Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai 980-8578, Japan.
出版信息
Org Lett. 2001 Jan 11;3(1):13-5. doi: 10.1021/ol000253x.
PMID:11429855
Abstract
[figure: see text] Mesityllithium was found to be an excellent selective lithiating agent to prepare aryllithium compounds having alkoxycarbonyl groups. To extend our studies on chemoselective lithiation, an important precursor for the synthesis of camptothecin was prepared using a halogen-lithium exchange reaction followed by an intramolecular 1,2-addition.
摘要
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