Tenn W J, French N L, Nagorski R W
Department of Chemistry, Illinois State University, Normal, Illinois 61790-4160, USA.
Org Lett. 2001 Jan 11;3(1):75-8. doi: 10.1021/ol0067944.
[figure: see text] The rate constants for the hydronium ion, hydroxide, and water-catalyzed breakdown of N-(hydroxymethyl)benzamide (1), 4-chloro-N-(hydroxymethyl)benzamide (2), and 2,4-dichloro-N-(hydroxymethyl)benzamide (3) in H2O, at 25 degrees C, I = 1.0 (KCl), have been determined. The reactions of 1, 2, and 3 were found to be specific acid and specific base catalyzed with a first-order dependence on hydronium and hydroxide ions. At higher hydroxide concentrations, the reactions were found to be pH independent for each compound studied.
[图：见正文] 已测定了25℃、离子强度I = 1.0（KCl）的水中，水合氢离子、氢氧根离子和水催化N-（羟甲基）苯甲酰胺（1）、4-氯-N-（羟甲基）苯甲酰胺（2）和2,4-二氯-N-（羟甲基）苯甲酰胺（3）分解的速率常数。发现1、2和3的反应是由特定酸和特定碱催化的，对水合氢离子和氢氧根离子呈一级依赖性。在较高的氢氧根浓度下，发现所研究的每种化合物的反应与pH无关。
