First synthesis of totally orthogonal protected alpha-(trifluoromethyl)- and alpha-(difluoromethyl)arginines.
作者信息
Moroni M, Koksch B, Osipov S N, Crucianelli M, Frigerio M, Bravo P, Burger K
机构信息
Institute of Organic Chemistry, University of Leipzig, Johannisallee 29, D-04103 Leipzig, Germany.
出版信息
J Org Chem. 2001 Jan 12;66(1):130-3. doi: 10.1021/jo0009043.
PMID:11429889
Abstract
The first synthesis of a series of totally orthogonal protected racemic alpha-(trifluoromethyl)- and alpha-(difluoromethyl)arginines is described. The key steps of the synthesis are the mild guanidinylation procedure and the selective hydrogenation of a CC triple bond in the presence of a Cbz-group.
摘要
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