Patthy A, Bajusz S, Patthy L
Acta Biochim Biophys Acad Sci Hung. 1977;12(3):191-6.
A simple procedure is described for the synthesis of N-guanidino methylated ariginines. The yields of all methylarginines exceed those obtained by earlier procedures. Trimethylarginine - an amino acid not found in natural sources - has also been synthesized with this technique. Studies with arginine specific dicarbonyl reagents showed that methylation of guanidino-groups decreases the reactivity of methyl-arginines, only monomethylarginine reacting at a rate comparable to that of arginine.
本文描述了一种合成N-胍基甲基化精氨酸的简单方法。所有甲基精氨酸的产率均超过了以往方法所获得的产率。利用该技术还合成了天然来源中未发现的氨基酸——三甲基精氨酸。对精氨酸特异性二羰基试剂的研究表明，胍基的甲基化会降低甲基精氨酸的反应活性，只有单甲基精氨酸的反应速率与精氨酸相当。
