Dettinger H M, Kurz G, Lehmann J
Carbohydr Res. 1979 Sep;74:301-7. doi: 10.1016/s0008-6215(00)84784-9.
2,6-Anhydro-3-deoxy-aldehydo-D-lyxo-hept-2-enose (7) and 2,6-anhydro-3-deoxy-D-lyxo-hept-2-enitol (8) were synthesized as half-chair analogs of D-galactal (1). As 1 is a strong inhibitor of, as well as a substrate for, beta-D-galactosidase from Escherichia coli, the same properties were expected for 7 and 8; however, both were ineffective. This result, together with those of other authors, allows speculative conclusions on the tight binding of 1 to the enzyme only, when water or an alcohol is bound as a co-substrate.
合成了2,6-脱水-3-脱氧-醛基-D-来苏-2-庚烯糖（7）和2,6-脱水-3-脱氧-D-来苏-2-庚烯醇（8）作为D-半乳糖醛（1）的半椅式类似物。由于1是大肠杆菌β-D-半乳糖苷酶的强抑制剂和底物，预计7和8也具有相同的性质；然而，两者均无效。这一结果与其他作者的结果一起，使得我们可以推测，只有当水或醇作为共底物结合时，1才会与该酶紧密结合。
