Isolation of symlandine from the roots of common comfrey (Symphytum officinale) using countercurrent chromatography.
作者信息
Kim N C, Oberlies N H, Brine D R, Handy R W, Wani M C, Wall M E
机构信息
Chemistry and Life Sciences, Research Triangle Institute, 3040 Cornwallis Road, Research Triangle Park, North Carolina 27709, USA.
出版信息
J Nat Prod. 2001 Feb;64(2):251-3. doi: 10.1021/np0004653.
PMID:11430014
Abstract
Three pyrrolizidine alkaloids, symlandine, symphytine, and echimidine (1-3), were isolated from the roots of Symphytum officinale using a one-step countercurrent chromatography procedure. The structures of 1-3 were confirmed by several spectroscopic techniques including 2D NMR methods. This is the first description of the separation of symlandine (1) from its stereoisomer, symphytine (2).
摘要
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