Wexler B C
Paroi Arterielle. 1975 May;2(4):221-39.
Male and female virgin rats and breeder rats with naturally-occurring diabetes, hypertension and arteriosclerosis, were made severely diabetic with a single, subcutaneous injection of alloxan (10 mg/100 g b.w.), after an 18 h fast. During five months of unrelenting diabetes, some animals became obese while others became emaciated. Only the emaciated animals survived but they were blind, their adrenal glands were hemorrhagic, hypertrophied and thrombosed, thymi involuted, kidneys swollen, hearts reduced in size while testes and ovaries were atrophic. Serum CPK, SGOT and SGPT were elevated concomitant with extensive cardiovascular damage, hepatic steatosis and generalized catabolism. Circulating triglycerides and free fatty acids were markedly elevated with total cholesterol only slightly increased. BUN and serum calcium levels were also greatly elevated. Sub-normal Cmpd. B levels indicated impaired adrenal steroidogenesis. Virgin rats developed arteriosclerosis and male and female breeder rats showed exacerbation of their pre-existing aortic sclerosis as well as P.A.N. lesions in their small-sized arteries. It is believed that severe diabetes causes exacerbation of the endogenous hormonal milieu resulting from abnormal hypothalamic-pituitary-adrenal function induced by repeated breeding, which conditions the connective tissue components of the arterial wall of rats toward accelerated degenerative changes.
雄性和雌性未交配大鼠以及患有自然发生的糖尿病、高血压和动脉硬化的种鼠，在禁食18小时后，通过单次皮下注射四氧嘧啶（10毫克/100克体重）使其患严重糖尿病。在持续五个月的糖尿病期间，一些动物变得肥胖，而另一些则消瘦。只有消瘦的动物存活下来，但它们失明，肾上腺出血、肥大且血栓形成，胸腺萎缩，肾脏肿胀，心脏变小，而睾丸和卵巢萎缩。血清肌酸磷酸激酶（CPK）、谷草转氨酶（SGOT）和谷丙转氨酶（SGPT）升高，同时伴有广泛的心血管损伤、肝脂肪变性和全身分解代谢。循环甘油三酯和游离脂肪酸显著升高，总胆固醇仅略有增加。血尿素氮（BUN）和血清钙水平也大幅升高。化合物B水平低于正常表明肾上腺类固醇生成受损。未交配大鼠发生动脉硬化，雄性和雌性种鼠显示其先前存在的主动脉硬化以及小动脉中的结节性多动脉炎（PAN）病变加重。据信，严重糖尿病会导致内源性激素环境恶化，这是由反复繁殖引起的下丘脑 - 垂体 - 肾上腺功能异常所致，这种异常使大鼠动脉壁的结缔组织成分朝着加速退行性变化发展。
