体外受精妊娠中的三联试验筛查
Triple-test screening in in vitro fertilization pregnancies.
作者信息
Bar-Hava I, Yitzhak M, Krissi H, Shohat M, Shalev J, Czitron B, Ben-Rafael Z, Orvieto R
机构信息
Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva, Israel.
出版信息
J Assist Reprod Genet. 2001 Apr;18(4):226-9. doi: 10.1023/a:1009455912670.
PURPOSE
To determine whether the results of triple-test analysis differ between spontaneous and IVF pregnancies.
METHODS
The study population consisted of 140 women with singleton pregnancies, 70 by IVF, and 70 by spontaneous conception. The groups were matched for maternal age, gestational week, and laboratory batch. The levels of all triple-test markers--alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG), and unconjugated estriol (u-E3)--were compared between the groups.
RESULTS
Significantly higher HCG levels were detected in the patients with IVF pregnancies than in the control group (1.31 +/- 0.8 vs. 0.95 +/- 0.5 multiple of the medians, respectively, (p < 0.006), but there were no significant differences in AFP or u-E3 levels. Overall, 18.5% of the IVF group were found to be screen-positive as compared with 11.4% of the control group (difference not statistically significant). Only 8 IVF pregnancies (11.4%) reached the lowest calculated risk possible (1:9999) compared with 17 (24.2%) in the control group (p < 0.05).
CONCLUSIONS
Our findings support previous data demonstrating elevated maternal serum HCG in IVF patients in comparison with spontaneous ones.
目的
确定三联试验分析结果在自然妊娠和体外受精（IVF）妊娠之间是否存在差异。
方法
研究人群包括140名单胎妊娠女性，其中70例通过IVF妊娠，70例通过自然受孕。两组在产妇年龄、孕周和实验室批次方面进行匹配。比较两组间所有三联试验标志物——甲胎蛋白（AFP）、人绒毛膜促性腺激素（HCG）和非结合雌三醇（u-E3）——的水平。
结果
IVF妊娠患者检测到的HCG水平显著高于对照组（分别为中位数的1.31±0.8倍和0.95±0.5倍，（p<0.006），但AFP或u-E3水平无显著差异。总体而言，IVF组18.5%的患者筛查呈阳性，而对照组为11.4%（差异无统计学意义）。与对照组的17例（24.2%）相比，IVF妊娠中只有8例（11.4%）达到了可能的最低计算风险（1:9999）（p<0.05）。
结论
我们的研究结果支持先前的数据，即与自然受孕患者相比，IVF患者的母体血清HCG升高。
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