• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

以美沙酮、吗啡或荷包牡丹碱作为非条件刺激对纹状体多巴胺代谢进行条件作用。

Conditioning of striatal dopamine metabolism with methadone, morphine or bulbocapnine as an unconditioned stimulus.

作者信息

Pérez-Cruet J

出版信息

Pavlov J Biol Sci. 1976 Oct-Dec;11(4):237-50. doi: 10.1007/BF03000317.

DOI:10.1007/BF03000317
PMID:11434
Abstract

Psychotropic drugs such as methadone, morphine and bulbocapnine produce increments in dopamine metabolism as an unconditioned reflex. When a buzzer noise is used as a conditioned stimulus (CS) with these drugs as unconditioned stimuli, the buzzer CS acquires the properties of the drugs in increasing dopamine metabolism. These results suggest that the brain, like other visceral organs, can be conditioned in terms of neurotransmitter release or metabolism.

摘要

美沙酮、吗啡和荷包牡丹碱等精神药物会作为一种非条件反射使多巴胺代谢增加。当将蜂鸣声用作条件刺激(CS),而将这些药物用作非条件刺激时,蜂鸣条件刺激在增加多巴胺代谢方面获得了这些药物的特性。这些结果表明,大脑与其他内脏器官一样,可以在神经递质释放或代谢方面形成条件反射。

相似文献

1
Conditioning of striatal dopamine metabolism with methadone, morphine or bulbocapnine as an unconditioned stimulus.以美沙酮、吗啡或荷包牡丹碱作为非条件刺激对纹状体多巴胺代谢进行条件作用。
Pavlov J Biol Sci. 1976 Oct-Dec;11(4):237-50. doi: 10.1007/BF03000317.
2
Inhibitory effects of bulbocapnine on dopamine biosynthesis in PC12 cells.荷包牡丹碱对PC12细胞中多巴胺生物合成的抑制作用。
Neurosci Lett. 1998 Mar 20;244(3):161-4. doi: 10.1016/s0304-3940(98)00148-7.
3
Conditioned stimulus control of morphine hyperthermia.吗啡热的条件性刺激控制
Psychopharmacology (Berl). 1990;101(1):77-84. doi: 10.1007/BF02253722.
4
Conditioning of morphine-induced locomotor activity and stereotyped behaviour in rats.
J Neural Transm Gen Sect. 1989;78(3):231-47. doi: 10.1007/BF01249232.
5
Once is too much: conditioned changes in accumbens dopamine following a single saccharin-morphine pairing.一次就够多了:单次糖精 - 吗啡配对后伏隔核多巴胺的条件性变化
Behav Neurosci. 2007 Dec;121(6):1234-42. doi: 10.1037/0735-7044.121.6.1234.
6
Dopamine efflux in nucleus accumbens shell and core in response to appetitive classical conditioning.伏隔核壳部和核心部位对经典性条件性奖赏刺激的多巴胺外流。
Eur J Neurosci. 2003 Sep;18(5):1306-14. doi: 10.1046/j.1460-9568.2003.02849.x.
7
Sensory and associative effects of morphine and naloxone in classical conditioning of the rabbit nictitating membrane response.吗啡和纳洛酮对家兔瞬膜反应经典条件反射的感觉和联合效应
Psychopharmacology (Berl). 1984;83(1):114-21. doi: 10.1007/BF00427434.
8
Morphine as a conditioned stimulus in a conditioned emotional response paradigm.吗啡作为条件性情绪反应范式中的条件刺激。
Psychopharmacology (Berl). 1993;112(2-3):277-84. doi: 10.1007/BF02244922.
9
Effects of morphine and LSD on the classically conditioned nictitating membrane response.吗啡和麦角酸二乙酰胺对经典条件反射性瞬膜反应的影响。
Pharmacol Biochem Behav. 1985 Jan;22(1):41-6. doi: 10.1016/0091-3057(85)90483-6.
10
Differential impact of pavlovian drug conditioned stimuli on in vivo dopamine transmission in the rat accumbens shell and core and in the prefrontal cortex.巴甫洛夫式药物条件刺激对大鼠伏隔核壳部、核心及前额叶皮质体内多巴胺传递的差异性影响。
Psychopharmacology (Berl). 2007 Apr;191(3):689-703. doi: 10.1007/s00213-006-0560-7. Epub 2006 Oct 28.

引用本文的文献

1
Fentanyl-induced conditional place preference: lack of associated conditional neurochemical events.芬太尼诱导的条件性位置偏爱:缺乏相关的条件性神经化学事件。
Psychopharmacology (Berl). 1988;96(4):534-40. doi: 10.1007/BF02180036.
2
Behavioral and physiological detection of classically-conditioned blood pressure reduction.经典条件反射性血压降低的行为学和生理学检测
Psychopharmacology (Berl). 1988;95(1):25-8. doi: 10.1007/BF00212760.
3
Conditioned locomotion and place preference elicited by tactile cues paired exclusively with morphine in an open field.

本文引用的文献

1
OPERANT PERFORMANCE BY RATS FOR ALCOHOL REINFORCEMENT. A COMPARISON OF ALCOHOL-PREFERRING AND NONPREFERRING ANIMALS.
Q J Stud Alcohol. 1964 Jun;25:226-34.
2
CONDITIONAL REFLEX ELECTROCARDIOGRAM OF BULBOCAPNINE: CONDITIONING OF THE T WAVE.
Am Heart J. 1964 Jan;67:61-72. doi: 10.1016/0002-8703(64)90399-0.
3
[Conditioned reflex cataleptic condition].
Zh Vyssh Nerv Deiat Im I P Pavlova. 1951 Jul-Aug;1(4):485-99.
4
[Method of the extraction and determination of homovanilic acid in tissues].
Boll Soc Ital Biol Sper. 1968 Mar 15;44(5):420-1.
在旷场中,仅与吗啡配对的触觉线索引发的条件性运动和位置偏好。
Psychopharmacology (Berl). 1987;91(3):375-80. doi: 10.1007/BF00518195.
4
Conditioning of morphine-induced locomotor activity and stereotyped behaviour in rats.
J Neural Transm Gen Sect. 1989;78(3):231-47. doi: 10.1007/BF01249232.
5
Self-administration of d-amphetamine by rats.大鼠对右旋苯丙胺的自我给药
Psychopharmacologia. 1968;12(2):158-63. doi: 10.1007/BF00401545.
6
The rate of norepinephrine synthesis measured in vivo during short intervals; influence of adrenergic nerve impulse activity.短时间内体内去甲肾上腺素合成的速率;肾上腺素能神经冲动活动的影响。
J Pharmacol Exp Ther. 1968 Feb;159(2):274-82.
7
Classical conditioning of a morphine abstinence phenomenon, reinforcement of opioid-drinking behavior and "relapse" in morphine-addicted rats.吗啡戒断现象的经典条件作用、阿片类药物饮用行为的强化以及吗啡成瘾大鼠的“复吸”
Psychopharmacologia. 1967;10(3):255-84. doi: 10.1007/BF00401386.
8
Accelerated synthesis of dopamine in the rat brain after methadone.美沙酮作用后大鼠脑内多巴胺的加速合成
Experientia. 1972 Aug 15;28(8):926. doi: 10.1007/BF01924950.
9
Psychological approaches to opiate dependence and self-administration by laboratory animals.
Fed Proc. 1970 Jan-Feb;29(1):2-5.
10
The fluorometric assay of catecholamines and related compounds: improvements and extensions to the hydroxyindole technique.儿茶酚胺及相关化合物的荧光测定法:对羟基吲哚技术的改进与扩展
Anal Biochem. 1968 Feb;22(2):269-79. doi: 10.1016/0003-2697(68)90316-3.