人类和鸡的伊洛魁（IRX）基因的克隆与染色体定位

Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes.

作者信息

Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T

机构信息

Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan.

出版信息

Cytogenet Cell Genet. 2001;92(3-4):320-5. doi: 10.1159/000056921.

DOI:10.1159/000056921

PMID:11435706

Abstract

Three highly homologous homeobox genes (caupolican, araucan and mirror) have been identified in Drosophila. These genes belong to the novel Iroquois complex, which acts as a pre-pattern molecule in Drosophila neurogenesis. Recently several vertebrate Iroquois homologues (Irx) were isolated and found to be involved in pattern formation of various tissues. Here we report cytogenetic mapping of four human and five chicken Iroquois genes by FISH. Our findings revealed that vertebrate Irx genes are clustered at two different loci.

摘要

在果蝇中已鉴定出三个高度同源的同源异型框基因（考波利坎、阿劳坎和镜像）。这些基因属于新型的易洛魁复合体，该复合体在果蝇神经发生过程中作为一种预模式分子发挥作用。最近，几个脊椎动物易洛魁同源基因（Irx）被分离出来，并发现它们参与各种组织的模式形成。在此，我们通过荧光原位杂交（FISH）报告了四个人类和五个鸡易洛魁基因的细胞遗传学定位。我们的研究结果表明，脊椎动物的Irx基因聚集在两个不同的位点。