Shingleton W B, Farabaugh P, Hughson M, Sewell P E
Division of Urology, Department of Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA.
J Urol. 2001 Jul;166(1):289-91.
We determined the feasibility of a percutaneous approach using magnetic resonance imaging (MRI) for creating cryoablation lesions in the porcine kidney.
Three domestic swine underwent renal cryoablation under MRI guidance with a total of 6 cryoablation lesions created in 5 kidneys. A 3 mm. cryoprobe was placed under MRI guidance using an interventional MRI unit. With a pressurized argon gas cooling unit the cryoablation lesion was created and monitored by MRI. Gross and histological examination of the kidneys was performed 1 week after the procedure.
All animals survived the procedure without difficulty. A total of 6 cryoablation lesions were produced in 5 kidneys. The lesions were 1.9 x 1.3 to 3.9 x 1.9 cm. on MRI. Histological examination 1 week after treatment showed that the lesions were 1.7 x 1.0 to 3.2 x 1.2 cm. There was an area of coagulation necrosis surrounded by a transition zone of inflammatory reaction a mean of 0.5 cm. in diameter with each lesion.
Percutaneous renal cryoablation using MRI imaging proved to be a successful technique for guiding probe placement and monitoring ice ball formation. Because MRI allows imaging in 3 planes, it may be useful for cryoablation of intraparenchymatous tumors.
我们确定了使用磁共振成像（MRI）经皮在猪肾脏中创建冷冻消融病灶的可行性。
三只家猪在MRI引导下进行肾脏冷冻消融，共在5个肾脏中创建了6个冷冻消融病灶。使用介入式MRI设备在MRI引导下放置一个3毫米的冷冻探针。通过加压氩气冷却装置创建冷冻消融病灶，并通过MRI进行监测。术后1周对肾脏进行大体和组织学检查。
所有动物手术过程均顺利存活。5个肾脏共产生6个冷冻消融病灶。MRI显示病灶大小为1.9×1.3至3.9×1.9厘米。治疗后1周的组织学检查显示病灶大小为1.7×1.0至3.2×1.2厘米。每个病灶均有一个凝固性坏死区域，周围是平均直径为0.5厘米的炎症反应过渡区。
使用MRI成像经皮肾脏冷冻消融被证明是一种成功的技术，可用于引导探针放置和监测冰球形成。由于MRI能够在三个平面成像，它可能对实质内肿瘤的冷冻消融有用。
