Sellers M T, Deierhoi M H, Curtis J J, Gaston R S, Julian B A, Lanier D C, Diethelm A G
Department of Surgery, University of Alabama at Birmingham, 701 South 19th Street, LHRB-728, Birmingham, AL 35294-0007, USA.
Transplantation. 2001 Jun 15;71(11):1681-3. doi: 10.1097/00007890-200106150-00031.
Despite significant advancements in clinical transplantation, very few reports describe the long-term acceptance of transplanted solid organs without indefinite immunosuppression. The immunosuppressive agents used are nonspecific and have serious potential side effects. We present a patient who received a living-donor renal allograft from the same person who had donated bone marrow to her several years earlier. Tolerance was expected based on previous acceptance of full-thickness skin grafts from the donor. Indeed, there has been no evidence of rejection during a 6-year follow-up period, and no induction or maintenance immunosuppression has been given. All noninvasive parameters of graft function remain normal. This and similar reports prove that genetically disparate solid organs can coexist without pharmacological immunosuppression.
尽管临床移植取得了重大进展，但很少有报告描述在没有长期免疫抑制的情况下移植实体器官的长期接受情况。所使用的免疫抑制剂是非特异性的，并且具有严重的潜在副作用。我们报告了一名患者，她接受了来自几年前曾为其捐献骨髓的同一个人的活体供肾移植。基于之前接受供体的全层皮肤移植，预计会出现免疫耐受。事实上，在6年的随访期内没有排斥反应的证据，并且未给予诱导或维持免疫抑制治疗。移植肾功能的所有非侵入性参数均保持正常。本报告及类似报告证明，基因不同的实体器官可以在没有药物免疫抑制的情况下共存。
