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侵袭性纤维瘤病（韧带样瘤）中Tcf-3表达及β-连环蛋白介导的转录激活

Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour).

作者信息

Tejpar S, Li C, Yu C, Poon R, Denys H, Sciot R, Van Cutsem E, Cassiman J J, Alman B A

机构信息

The Program in Developmental Biology, The Hospital for Sick Children and the University of Toronto, 555 University Avenue, Toronto, Ontario, M5G1X8, Canada

出版信息

Br J Cancer. 2001 Jul 6;85(1):98-101. doi: 10.1054/bjoc.2001.1857.

DOI:10.1054/bjoc.2001.1857
PMID:11437409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2363921/
Abstract

Aggressive fibromatosis harbours mutations resulting in beta-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that beta-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by beta-catenin stabilization in a human neoplastic process.

摘要

侵袭性纤维瘤病存在导致β-连环蛋白稳定的突变。原代细胞培养显示侵袭性纤维瘤病中存在组成性的tcf激活。表达和免疫共沉淀研究表明，β-连环蛋白在该肿瘤中结合并激活tcf-3。这是在人类肿瘤形成过程中首次证明由β-连环蛋白稳定化激活tcf-3。

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本文引用的文献

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Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor).环氧化酶-2（COX-2）调节侵袭性纤维瘤病（韧带样瘤）中的细胞增殖。
Oncogene. 2001 Jan 25;20(4):451-60. doi: 10.1038/sj.onc.1204107.
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Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation.胃癌细胞系MKN28中TCF-3过表达诱导的丝裂霉素C耐药与DT-黄递酶下调有关。
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Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways.Wnt/β-连环蛋白和Wnt/Ca2+信号通路的信号转导机制与功能
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Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor).散发性侵袭性纤维瘤病（硬纤维瘤）中β-连环蛋白突变和β-连环蛋白失调占主导地位。
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PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs.过氧化物酶体增殖物激活受体δ是一种受非甾体抗炎药调控的结肠腺瘤性息肉病蛋白的靶标。
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