Nishio S, Morioka T, Suzuki S, Hirano K, Fukui M
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
J Clin Neurosci. 2001 Jul;8(4):335-9. doi: 10.1054/jocn.2000.0793.
The clinical and morphological features of eight patients with meningothelial meningiomas with numerous pseudopsammoma bodies (secretory meningiomas) are presented. The six female and two male patients ranged in age from 43 to 68 years. Tumours were located at the petroclival region in two, the lateral parasellar region in two, the petrous apex in one and the sphenoid ridge in three patients. On magnetic resonance imaging, they were iso or hypointense on T1-weighted images, and hyper or isointense on T 2-weighted images. Peritumoral brain edema was absent in five cases, and was mild to moderate in three cases. Serum carcinoembryonic antigen (CEA) levels were measured preoperatively in three patients, with one having an elevated serum CEA level which re turned to normal following tumour resection. Immunohistochemical analysis on the resected tumour tissues, pseudopsammoma bodies and surrounding tumour cells were shown to be CEA-positive. Ultrastructurally, pseudopsammoma bodies were composed of granular and filamentous materials located predominantly in the intracellular lumina, which were lined by microvilli. While these morphological features of focal epithelial and secretory differentiation of tumour cells call attention to the broad spectrum of differentiation properties of meningiomas, the biological behavior of the eight tumours reported herein corresponded to those of meningiomas in general.
本文介绍了8例伴有大量假砂粒体（分泌性脑膜瘤）的脑膜皮型脑膜瘤患者的临床和形态学特征。6例女性和2例男性患者年龄在43至68岁之间。肿瘤位于岩斜区2例，鞍旁外侧区2例，岩尖1例，蝶骨嵴3例。在磁共振成像上，它们在T1加权图像上呈等信号或低信号，在T2加权图像上呈高信号或等信号。5例患者无瘤周脑水肿，3例患者有轻度至中度瘤周脑水肿。术前对3例患者检测血清癌胚抗原（CEA）水平，其中1例患者血清CEA水平升高，肿瘤切除后恢复正常。对切除的肿瘤组织、假砂粒体和周围肿瘤细胞进行免疫组织化学分析，结果显示CEA呈阳性。超微结构上，假砂粒体由主要位于细胞内管腔的颗粒状和丝状物质组成，管腔内衬有微绒毛。虽然肿瘤细胞的局灶性上皮和分泌分化的这些形态学特征引起了人们对脑膜瘤广泛分化特性的关注，但本文报道的8例肿瘤的生物学行为与一般脑膜瘤的生物学行为一致。
