Malhi G S, Mitchell P B, Caterson I
Mood Disorders Unit, The Villa, Prince of Wales Hospital, Randwick, NSW, Australia.
Aust N Z J Psychiatry. 2001 Jun;35(3):315-21. doi: 10.1046/j.1440-1614.2001.00891.x.
Weight gain associated with the use of psychotropic medications is a common clinical problem that is of particular importance because of its effects on the general health of psychiatric patients and their compliance with treatment. This paper aims to explore this issue and discuss the mechanisms of weight gain and methods of prevention.
A literature review (Index Medicus/Medline) was carried out as well as a review of other relevant papers and data known to the authors.
Significant weight gain may result in considerable morbidity. The majority of psychotropic medications are associated with weight gain, however, the mechanisms of weight gain are often complex and poorly understood.
Clinically, weight gain can be anticipated and often managed with some success in the majority of psychiatric patients with simple but relatively effective measures. It is important for clinicians to be aware of this common clinical problem and educate patients from the outset, monitoring them regularly and intervening when necessary.
与使用精神药物相关的体重增加是一个常见的临床问题，因其对精神病患者的总体健康及其治疗依从性有影响，故而尤为重要。本文旨在探讨这一问题，并讨论体重增加的机制及预防方法。
进行了文献综述（医学索引/医学期刊数据库），并对作者所知的其他相关论文和数据进行了回顾。
显著的体重增加可能导致相当高的发病率。大多数精神药物都与体重增加有关，然而，体重增加的机制往往很复杂，人们对此了解甚少。
临床上，体重增加是可以预见的，并且通过一些简单但相对有效的措施，大多数精神病患者通常能够成功应对。临床医生认识到这一常见的临床问题并从一开始就对患者进行教育很重要，要定期对他们进行监测，并在必要时进行干预。
