大豆黄素对抑制成骨细胞MC3T3-E1细胞增殖及促进其分化的作用。
Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells.
作者信息
Yoshida H, Teramoto T, Ikeda K, Yamori Y
机构信息
Graduate School of Human and Environmental Studies, Kyoto University, Japan.
出版信息
Biosci Biotechnol Biochem. 2001 May;65(5):1211-3. doi: 10.1271/bbb.65.1211.
PMID:11440142
Abstract
Glycitein, as one of the three major isoflavones in soybeans, directly but significantly (about 5%) suppressed the proliferation of MC3T3-E1 and stimulated bone-related protein (alkaline phosphatase (ALP) and osteocalcin (OC)) expression. These results indicate that glycitein suppresses the proliferation of osteoblasts and promotes differentiation from its progenitor.
摘要
黄豆苷元作为大豆中三种主要异黄酮之一，直接且显著地（约5%）抑制了MC3T3-E1细胞的增殖，并刺激了骨相关蛋白（碱性磷酸酶（ALP）和骨钙素（OC））的表达。这些结果表明，黄豆苷元抑制成骨细胞的增殖，并促进其祖细胞的分化。
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