Yildiz A, Colak T, Güngör F, Ozuğur S, Boz A, Tunçdemir F, Akaydin M
Akdeniz University, Faculty of Medicine, Department of Nuclear Medicine, Antalya, Turkey.
Rev Esp Med Nucl. 2001 Jun;20(4):276-81. doi: 10.1016/s0212-6982(01)71958-1.
This study has aimed to determine the diagnostic value of the scintimammography with 99mTc-MIBI in the detection of primary breast cancer and to verify its clinical usefulness. Sixty-three female patients (age range 27-83) with breast lesions detected by physical examination, ultrasonography, and/or mammography were prospectively included in this study. An anterior and prone lateral planar 99mTc-MIBI scintimammography was performed on all patients. The final diagnosis was achieved by histopathological examination in 49 patients and clinical followup (at least one year) in 14 patients. Histopathological diagnosis confirmed that 15 lesions were malignant and 34 lesions were benign. All the malignant lesions were larger than 1 cm. The 99mTc-MIBI scintimammography showed increased focal uptake in 17 lesions (two of them were benign and the other 15 were malignant). The diffuse heterogeneous uptake pattern was considered as benign. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy values for breast carcinoma were calculated as 100%, 96%, 88%, 100%, 97%, respectively. We concluded that 99mTc-MIBI scintimammography could be a valuable method in the differentiation of malignant breast neoplasm larger than 1 cm size from benign ones, especially when the uptake pattern was considered.
本研究旨在确定99mTc-MIBI乳腺闪烁显像在原发性乳腺癌检测中的诊断价值，并验证其临床实用性。本研究前瞻性纳入了63例经体格检查、超声检查和/或乳腺X线摄影发现乳腺病变的女性患者（年龄范围27 - 83岁）。对所有患者进行了前位和俯卧侧位平面99mTc-MIBI乳腺闪烁显像。49例患者通过组织病理学检查获得最终诊断，14例患者通过临床随访（至少1年）获得最终诊断。组织病理学诊断证实15个病变为恶性，34个病变为良性。所有恶性病变均大于1 cm。99mTc-MIBI乳腺闪烁显像显示17个病变有局灶性摄取增加（其中2个为良性，另外15个为恶性）。弥漫性不均匀摄取模式被认为是良性的。乳腺癌的敏感性、特异性、阳性预测值、阴性预测值和准确性分别计算为100%、96%、88%、100%、97%。我们得出结论，99mTc-MIBI乳腺闪烁显像可能是一种有价值的方法，用于区分大于1 cm大小的恶性乳腺肿瘤与良性肿瘤，尤其是考虑摄取模式时。
