前列腺素E1、前列腺素E2的致炎及扭体综合征诱导作用以及对这些作用的抑制
Inflammation and writhing syndrome inducing effect of PGE1, PGE2 and the inhibition of these actions.
作者信息
Gyires K, Knoll J
出版信息
Pol J Pharmacol Pharm. 1975 May-Jun;27(3):257-64.
PMID:1144205
Abstract
The inflammatory and nociception inducing effect of PGE1 and PGE2, and the inhibition of these actions were studied. The inflammatory effect was produced in rat paw by intradermal injection of PG. Both PGE1 and PGE2 in doses of 500 ng produced maximal inflammatory and vascular permeability increasing effects. With higher doses these responses decreased. Antiserotonin, antihistamine drugs partly antagonized the above mentioned effects of PG.
摘要
研究了前列腺素E1（PGE1）和前列腺素E2（PGE2）的炎症和诱导伤害感受作用，以及对这些作用的抑制情况。通过皮内注射前列腺素（PG）在大鼠爪部产生炎症效应。500纳克剂量的PGE1和PGE2均产生最大的炎症和增加血管通透性的效应。剂量更高时，这些反应会减弱。抗血清素、抗组胺药物可部分拮抗PG的上述作用。
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