Effect of various pharmacological agents on prostaglandin induced increases in microvascular permeability.

The anti-histamines, pyrilamine and chlorpheniramine, the serotonin antagonist, methysergide, the beta-adrenolytic, phenoxybenzamine and the anti-cholinergic, atropine, antagonized the prostaglandin E1 induced increases in vascular permeability. None of the non-steroidal anti-inflammatory agents acted as antagonists at these doses.