新型三环类抗抑郁药10-(3-二甲氨基丙基)-7-氯苯并-(b),(1,8)-萘啶酮-5单盐酸盐（IF-C-45）长期治疗期间大鼠脑和心脏组织中的儿茶酚胺浓度及其血压
Catecholamines concentration in brain and heart tissue of rats and its blood pressure during chronic treatment with a new tricyclic antidepressant 10-(3-dimethylaminopropyl)-7-chlorobenzo-(b), (1,8)-naphthyridone-5 monohydrochloride (IF-C-45).
作者信息
Filczewski M, Szymańska-Kosmala M
出版信息
Pol J Pharmacol Pharm. 1975 May-Jun;27(3):277-82.
PMID:1144206
Abstract
DA concentration in brain tissue decreased statisticaly after 3, 6 and 9 weeks, NA concentration also statisticaly decreased but after 3 weeks only. The NA concentration in heart tissue decreased statisticaly significant in all investigated animals. There were no statisticaly significant changes in blood pressure.
摘要
3周、6周和9周后，脑组织中的多巴胺（DA）浓度有统计学意义的下降，去甲肾上腺素（NA）浓度也有统计学意义的下降，但仅在3周后出现。在所有被研究的动物中，心脏组织中的去甲肾上腺素浓度有统计学意义的显著下降。血压没有统计学意义上的显著变化。
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