简短报告：针对重组ypfmsp119各种类似物的IgG1/IgG3抗体反应——对生活在恶性疟原虫传播地区的免疫成年人的一项研究
Short report: IgG1/IgG3 antibody responses to various analogs of recombinant ypfmsp119--a study in immune adults living in areas of Plasmodium falciparum transmission.
作者信息
Diallo T O, Spiegel A, Diouf A, Perraut R, Kaslow D C, Garraud O
机构信息
Unité d'Immunologie, Institut Pasteur, Dakar, Sénéga.
出版信息
Am J Trop Med Hyg. 2001 Mar-Apr;64(3-4):204-6. doi: 10.4269/ajtmh.2001.64.204.
To further characterize protective-type (IgG1/IgG3) antibody responses to Plasmodium falciparum blood stage in putatively immune individuals' plasma, we have tested for various analogs of the 19 kDa C-terminus of the MSP1 antigen obtained as secreted recombinant proteins from Saccharomyces cerevisiae. One of four proteins was then identified on the basis of consistent IgG3, along with less variable IgG1 recognition. This protein has thus been selected for further functional assays of IgG1/IgG3 antibodies.
为了进一步表征假定免疫个体血浆中针对恶性疟原虫血液阶段的保护性抗体（IgG1/IgG3）反应，我们检测了从酿酒酵母中分泌的重组蛋白获得的MSP1抗原19 kDa C末端的各种类似物。然后根据一致的IgG3以及变化较小的IgG1识别，从四种蛋白中鉴定出一种。因此，已选择该蛋白用于IgG1/IgG3抗体的进一步功能测定。
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