Masud T, Jordan D, Hosking D J
Clinical Gerontological Research Unit and. Department of Medicine, City Hospital, Nottingham NG5 1PB, UK.
Age Ageing. 2001 May;30(3):255-8. doi: 10.1093/ageing/30.3.255.
to assess the prevalence of a history of Colles' fracture (occurring after the age of 40 years) and to ascertain the extent of investigation and treatment of osteoporosis in this population.
we studied subjects aged > or =60 years from the age-sex register of three general practices. We recorded a history of fractures and details of any previous investigation for osteoporosis and treatment with bone-protective drugs. Bone mineral density was performed at the heel using dual-energy x-ray absorptiometry (Lunar PIXI machine). We classified subjects into normal, osteopaenic or osteoporotic according to the machine manufacturer's recommended World Health Organisation 'equivalent T-score thresholds' (0.6 for osteopaenia and 1.6 for osteoporosis).
of the 605 subjects invited, we recruited 259 women and 194 men (response rate=74.8%). Twenty-eight (10.8%) of the women and five (2.6%) of the men had a history of Colles' fracture. Of women with a prevalent Colles' fracture, 39% were osteoporotic and 36% were osteopaenic. These rates were significantly greater than in women without a Colles' fracture (19.9% osteoporotic, 29.4% osteopaenic; P=0.018). Assuming the same PIXI thresholds for men, two (40%) of the five men with a history of Colles' fractures were osteoporotic and the rest were osteopaenic, compared with 20.6 and 31.2% of men without a history of Colles' fractures. None of the subjects in the Colles' fracture group had previously been investigated with bone densitometry. Women with and without a history of Colles' fracture did not differ significantly in ever having (32.1% vs 27.2%; P=0.4) or currently having (14.3% vs 10.4%; P=0.4) hormone replacement treatment. None of the men and only one woman with a previous Colles' fracture had ever taken a non-hormone replacement treatment for osteoporosis.
older community-dwelling subjects with previous Colles' fracture have a high prevalence of osteoporosis and are under-investigated and under-treated. Methods for identifying subjects with a previous Colles' fracture need to be developed in primary and secondary care.
评估科雷氏骨折(40岁以后发生)病史的患病率,并确定该人群中骨质疏松症的检查和治疗程度。
我们从三个全科医疗的年龄-性别登记册中研究年龄≥60岁的受试者。我们记录了骨折病史以及之前任何骨质疏松症检查和使用骨保护药物治疗的详细情况。使用双能X线吸收法(Lunar PIXI仪器)在足跟部测量骨密度。根据仪器制造商推荐的世界卫生组织“等效T值阈值”(骨质疏松症为0.6,骨质疏松为1.6),我们将受试者分为正常、骨量减少或骨质疏松。
在邀请的605名受试者中,我们招募了259名女性和194名男性(应答率=74.8%)。28名(10.8%)女性和5名(2.6%)男性有科雷氏骨折病史。在有科雷氏骨折病史的女性中,39%为骨质疏松,36%为骨量减少。这些比例显著高于无科雷氏骨折病史的女性(骨质疏松19.9%,骨量减少29.4%;P=0.018)。假设男性采用相同的PIXI阈值,有科雷氏骨折病史的5名男性中有2名(40%)为骨质疏松,其余为骨量减少,而无科雷氏骨折病史的男性分别为20.6%和31.2%。科雷氏骨折组的受试者之前均未接受过骨密度测定检查。有和无科雷氏骨折病史的女性在曾经接受过(32.1%对27.2%;P=0.4)或目前正在接受(14.3%对10.4%;P=0.4)激素替代治疗方面无显著差异。有科雷氏骨折病史的男性均未接受过骨质疏松症的非激素替代治疗,只有一名女性接受过。
既往有科雷氏骨折的社区老年受试者骨质疏松症患病率高,检查和治疗不足。需要在初级和二级医疗保健中制定识别既往有科雷氏骨折受试者的方法。