Bener A, Denic S, Al-Mazrouei M
Department of Community Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Cancer. 2001 Jul 1;92(1):1-6. doi: 10.1002/1097-0142(20010701)92:1<1::aid-cncr1284>3.0.co;2-y.
In native population of the United Arab Emirates (UAE), the rate of consanguineous marriages is 50.5%. This study was designed to determine whether the rates of consanguinity and family history of cancer among the families of children with lymphoid malignancy are different from those in the general population.
The study comprised 117 patients from the whole of the country with acute lymphocytic leukemia (ALL) and Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), ranging in age from 2 to 14 years. The consanguinity rate in the study group was compared with the rate in the general population. To study family history of cancer, the authors matched patients with 117 controls. In a telephone interview, each mother was asked to provide data regarding the biologic relationship between her and her husband as well as that between both sets of grandparents; each was also asked whether any family relative had a cancer and, if so, of what type.
Among the 69 ALL cases, 80% of families were consanguineous and 20% were nonconsanguineous. Among the 26 NHL and 22 HL cases, each group included 3 consanguineous families, 12% and 14%, respectively. The consanguinity rates for ALL, NHL, and HL were all significantly different from the 50.5% consanguinity rate in the UAE population (all three P values < 0.0001). The family history of cancer was more often positive in ALL patients than in controls (odds ratio, 2.14; confidence interval, 1.01--4.53). Overall and for each lymphoid malignancy, there was no difference in family history of cancer between consanguineous and nonconsanguineous groups of cases.
The consanguinity rate in the families of patients with ALL is significantly higher and in those with NHL and HL significantly lower than that in the UAE population. The family history of cancer is more often positive among ALL cases than controls--consanguinity having no effect.
在阿拉伯联合酋长国（UAE）的本地人口中，近亲结婚率为50.5%。本研究旨在确定淋巴系统恶性肿瘤患儿家庭中的近亲结婚率和癌症家族史是否与普通人群不同。
该研究纳入了来自全国的117例急性淋巴细胞白血病（ALL）、霍奇金淋巴瘤（HL）和非霍奇金淋巴瘤（NHL）患者，年龄在2至14岁之间。将研究组的近亲结婚率与普通人群的进行比较。为研究癌症家族史，作者将患者与117名对照进行匹配。在电话访谈中，要求每位母亲提供有关她与丈夫以及双方祖父母之间生物学关系的数据；还询问了是否有任何家族亲属患癌症，以及患何种癌症。
在69例ALL病例中，80%的家庭为近亲结婚，20%为非近亲结婚。在26例NHL和22例HL病例中，每组分别有3个近亲结婚家庭，分别占12%和14%。ALL、NHL和HL的近亲结婚率均与阿联酋人群50.5%的近亲结婚率有显著差异（所有三个P值均<0.0001）。ALL患者的癌症家族史阳性率高于对照组（优势比，2.14；置信区间，1.01 - 4.53）。总体而言，对于每种淋巴系统恶性肿瘤，近亲结婚和非近亲结婚病例组之间的癌症家族史没有差异。
ALL患者家庭中的近亲结婚率显著高于阿联酋人群，而NHL和HL患者家庭中的近亲结婚率显著低于阿联酋人群。ALL病例的癌症家族史阳性率高于对照组——近亲结婚对此无影响。
