Faculty of Medicine, Damascus University, Damascus, Syria.
Haematology Department, Children's University Hospital, Damascus University, Damascus, Syria.
Biomed Res Int. 2020 Dec 8;2020:7919310. doi: 10.1155/2020/7919310. eCollection 2020.
Acute lymphoblastic leukemia (ALL) is a common malignancy in children. Consanguinity has a high prevalence in developing countries and increases the probability of homozygosity for many genes which may affect ALL and its prognosis. We conducted a study to explore the impact of consanguinity and number of siblings on ALL as there are currently no studies to describe this effect. Data were collected from patients' records from the Children's University Hospital of Damascus University, which is the major cancer centre for children in Syria. This study included 193 children with ALL over one year. Number of siblings was not with the French-American-British (FAB) classification, gender, ALL subtype, or risk of ALL children. When comparing consanguinity degrees and complete blood counts at diagnosis, significant contradicting data were found in the third-degree and fourth-degree consanguinity when compared to one another and to not having consanguineous parents as third degree consanguinity was associated with normal platelets but lower WBC counts, and fourth-degree consanguinity was associated with normal haemoglobin levels and WBC counts, but lower platelet counts. Having consanguineous parents was also associated with acquiring ALL at an older age, L2 FAB classification, having a positive family history for malignancies, and not having hepatosplenomegaly ( < 0.05). Although L2 is known to be a poor prognosis indicatory, no association was found with consanguinity and risk. Finally, no association was found with ALL subtype or risk ( > 0.05). Although consanguinity and number of siblings have affected some variables and prognostic features of childhood ALL, the aetiology is not clear and we need further studies to clarify such an association as this will help in optimising therapy and accurately determine the risk.
急性淋巴细胞白血病 (ALL) 是儿童常见的恶性肿瘤。在发展中国家，近亲结婚的现象较为普遍，增加了许多基因纯合的可能性，这些基因可能会影响 ALL 及其预后。我们进行了一项研究，探讨近亲结婚和兄弟姐妹数量对 ALL 的影响，因为目前尚无研究描述这种影响。数据来自大马士革大学儿童大学医院的患者记录，该医院是叙利亚儿童癌症的主要中心。这项研究包括 193 名一年以上的 ALL 患儿。兄弟姐妹数量与 French-American-British（FAB）分类、性别、ALL 亚型或 ALL 患儿的风险无关。在比较血缘关系程度和诊断时的全血细胞计数时，发现第三级和第四级血缘关系之间存在显著矛盾的数据，与没有血缘关系的父母相比，第三级血缘关系与正常血小板但较低的白细胞计数有关，第四级血缘关系与正常血红蛋白水平和白细胞计数有关，但血小板计数较低。有血缘关系的父母也与年龄较大、L2 FAB 分类、有恶性肿瘤家族史和无肝脾肿大（<0.05）有关。尽管 L2 已知是预后不良的指标，但与血缘关系和风险无关。最后，与 ALL 亚型或风险无关（>0.05）。尽管血缘关系和兄弟姐妹数量影响了儿童 ALL 的一些变量和预后特征，但病因尚不清楚，我们需要进一步研究以澄清这种关联，因为这将有助于优化治疗并准确确定风险。
