苯巴比妥对甲基汞肾毒性的保护作用。
Phenobarbital protection against methyl mercury neophrotoxicity.
作者信息
Fowler B A, Lucier G W
出版信息
Proc Soc Exp Biol Med. 1975 May;149(1):75-9. doi: 10.3181/00379727-149-38746.
PMID:1144447
Abstract
Phenobarbital injections to rats given a low oral dose level of methl mercury for 2 or 4 wk decreased methyl mercury-induced ultrastructural alterations in kidney proximal tubule cells, increased urinaryexcretion of inorganic mercury and increased blood concentrations of methylmercury. These effects were not seen after 2 wk of treatment but were highly significant after 4 wk.
摘要
给大鼠口服低剂量甲基汞2周或4周后，注射苯巴比妥可减少甲基汞诱导的肾近端小管细胞超微结构改变，增加无机汞的尿排泄，并提高甲基汞的血药浓度。这些作用在治疗2周后未观察到，但在4周后非常显著。
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