左氧氟沙星与华法林的相互作用。

Levofloxacin and warfarin interaction.

作者信息

Ravnan S L, Locke C

机构信息

University of the Pacific School of Pharmacy and Health Science, Sockton, California, 95221, USA.

出版信息

Pharmacotherapy. 2001 Jul;21(7):884-5. doi: 10.1592/phco.21.9.884.34559.

DOI:10.1592/phco.21.9.884.34559

PMID:11444586

Abstract

Numerous case reports have documented an enhanced hypoprothrombinemic effect caused by an interaction between fluoroquinolones (most notably, ciprofloxacin) and warfarin sodium. Conflicting data exist regarding the clinical significance of this interaction. Two patients who had elevated international normalized ratios after receiving concurrent levofloxacin and warfarin sodium are described.

摘要

众多病例报告记录了氟喹诺酮类药物（最显著的是环丙沙星）与华法林钠之间的相互作用导致凝血酶原减少效应增强。关于这种相互作用的临床意义，存在相互矛盾的数据。本文描述了两名在同时接受左氧氟沙星和华法林钠治疗后国际标准化比值升高的患者。