Pi-Sunyer F X
Proc Soc Exp Biol Med. 1975 Jul;149(3):693-7. doi: 10.3181/00379727-149-38881.
The effect of fatty acids on insulin secretion in vitro was investigated. Pieces of pancreas from fed rats were incubated for 15 or 90 min at low (0.6 mg/ml) and high (3.0 mg/ml) glucose concentrations with and without either sodium octanoate or sodium oleate. A highly significant difference in insulin secretion between low and high glucose concentrations indicated viability and responsiveness of the incubated tissue. No statistically significant effect of octanoate or oleate on insulin secretion was found at either low or high glucose concentration. Thus, no support was found for the concept that medium- and long-chain free fatty acids are insulin secretagogues.
研究了脂肪酸对体外胰岛素分泌的影响。将喂食大鼠的胰腺组织块在低（0.6毫克/毫升）和高（3.0毫克/毫升）葡萄糖浓度下，分别在有和没有辛酸钠或油酸钠的情况下孵育15或90分钟。低葡萄糖浓度和高葡萄糖浓度之间胰岛素分泌存在高度显著差异，表明孵育组织具有活力和反应性。在低葡萄糖浓度或高葡萄糖浓度下，均未发现辛酸盐或油酸盐对胰岛素分泌有统计学显著影响。因此，没有证据支持中链和长链游离脂肪酸是胰岛素促分泌剂这一概念。
