Savaskan E, Hock C, Olivieri G, Bruttel S, Rosenberg C, Hulette C, Müller-Spahn F
Department of Psychiatry, University of Basel, Wilhelm Klein-Str.27, CH-4054, Basel, Switzerland.
Neurobiol Aging. 2001 Jul-Aug;22(4):541-6. doi: 10.1016/s0197-4580(00)00259-1.
We investigated the immunohistochemical alterations of angiotensin converting enzyme (ACE), angiotensin II and AT1 receptor in the parietal cortex in Alzheimer's dementia (AD) to reveal the contributive role of the brain renin-angiotensin system in the disease process. In controls, ACE, angiotensin II and AT1 immunoreactivities were localized to pyramidal neurons of the cortex. The staining intensity was distinctly increased in AD for all three antigens, involving predominantly cortical layer V, which may reflect the enhanced brain renin-angiotensin system activity in the disease process. In addition, a prominent perivascular ACE and angiotensin II immunoreactivity surrounding some cortical vessels in aged controls and AD patients points to an underlying microvascular pathology in the process of neurodegeneration.
我们研究了阿尔茨海默病（AD）患者顶叶皮质中血管紧张素转换酶（ACE）、血管紧张素II和AT1受体的免疫组化改变，以揭示脑肾素-血管紧张素系统在疾病过程中的作用。在对照组中，ACE、血管紧张素II和AT1免疫反应定位于皮质的锥体细胞。在AD患者中，这三种抗原的染色强度均明显增加，主要累及皮质第V层，这可能反映了疾病过程中脑肾素-血管紧张素系统活性增强。此外，在老年对照组和AD患者中，一些皮质血管周围有明显的血管周围ACE和血管紧张素II免疫反应，提示神经退行性变过程中存在潜在的微血管病变。
