Svendsen F, Hugdahl K, Wester K
Nevrokirurgisk avdeling Haukeland Sykehus 5021 Bergen.
Tidsskr Nor Laegeforen. 2001 May 30;121(14):1683-6.
Normal pressure hydrocephalus (NPH) is an important diagnosis to keep in mind, i.e. the possibility that NPH and not a neurodegenerative disease causes the patient's symptoms with ataxia, urinary incontinence and dementia. Clinical improvement, sometimes a complete reversal of the symptoms, may be seen after a simple surgical procedure. This prospective study was performed by testing eight consecutively shunted patients with a walking test and a cognitive test battery pre- and postoperatively. Improvement 3-4 months after the shunting procedure suggests that NPH was present in six of eight patients. Walking ability was improved after surgery, also in patients with severe dementia. Severe dementia caused by NPH is hardly reversible, though cognitive tests may indicate some improvement. However, early surgical treatment of NPH in patients not suffering from a dementia according to the Mini Mental Status Test may bring improvement in some cognitive functions. Patients with both clinical and radiological signs of normal pressure hydrocephalus should be offered a shunting procedure.
正常压力脑积水(NPH)是一个需要牢记的重要诊断,即NPH而非神经退行性疾病导致患者出现共济失调、尿失禁和痴呆症状的可能性。在进行简单的手术后,有时可观察到临床症状改善,甚至症状完全逆转。本前瞻性研究通过对8例连续接受分流手术的患者在术前和术后进行步行测试和认知测试组来开展。分流手术后3 - 4个月的症状改善表明,8例患者中有6例存在NPH。术后步行能力得到改善,重度痴呆患者也是如此。由NPH导致的重度痴呆几乎不可逆转,尽管认知测试可能显示有一定改善。然而,对于根据简易精神状态测试未患痴呆的NPH患者,早期手术治疗可能会使某些认知功能得到改善。具有正常压力脑积水临床和影像学特征的患者应接受分流手术。