用灭活的无荚膜全细胞进行鼻内免疫可预防有荚膜肺炎球菌的定植和侵袭性疾病。
Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci.
作者信息
Malley R, Lipsitch M, Stack A, Saladino R, Fleisher G, Pelton S, Thompson C, Briles D, Anderson P
机构信息
Divisions of Infectious Diseases, Children's Hospital, Harvard University of Public Health, Boston, Massachusetts 02115, USA.
出版信息
Infect Immun. 2001 Aug;69(8):4870-3. doi: 10.1128/IAI.69.8.4870-4873.2001.
Abstract
A whole-cell killed unencapsulated pneumococcal vaccine given by the intranasal route with cholera toxin as an adjuvant was tested in two animal models. This vaccination was highly effective in preventing nasopharyngeal colonization with an encapsulated serotype 6B strain in mice and also conferred protection against illness and death in rats inoculated intrathoracically with a highly encapsulated serotype 3 strain. When the serotype 3 challenge strain was incubated in the sera of immunized rats, it was no longer virulent in an infant-rat sepsis model, indicating that the intranasal immunization elicited protective systemic antibodies. These studies suggest that killed whole-cell unencapsulated pneumococci given intranasally with an adjuvant may provide multitypic protection against capsulated pneumococci.
摘要
一种通过鼻内途径给予并以霍乱毒素作为佐剂的全细胞灭活非包膜肺炎球菌疫苗在两种动物模型中进行了测试。这种疫苗接种在预防小鼠被6B型包膜菌株进行鼻咽部定植方面非常有效，并且在经胸腔接种高包膜3型菌株的大鼠中也能提供针对疾病和死亡的保护。当3型攻击菌株在免疫大鼠的血清中孵育时，它在幼鼠败血症模型中不再具有毒性，这表明鼻内免疫引发了保护性全身抗体。这些研究表明，鼻内给予佐剂的灭活全细胞非包膜肺炎球菌可能提供针对包膜肺炎球菌的多型保护。
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