Fattore L, Cossu G, Martellotta M C, Deiana S, Fratta W
Department of Neuroscience, University of Cagliari and Centre for Neuropharmacology, CNR, Cittadella Universitaria, 09042 Monserrato, Cagliari, Italy.
Neuroreport. 2001 Jul 20;12(10):2243-6. doi: 10.1097/00001756-200107200-00039.
gamma-Hydroxybutyric acid (GHB) is a widely used recreational drug known to exert positive reinforcing effects in animals and humans. The GABA(B) receptor agonist baclofen has been proved to possess antimotivational effect and to inhibit alcohol, cocaine, heroin and nicotine intake. In the present study we evaluated the effect of baclofen on i.v. self-administration of GHB in drug-naive mice under a fixed-ratio (FR-1) schedule of reinforcement and nose-poking-like response as operandum. Results show that baclofen was able to completely prevent GHB seeking behaviour, decreasing the rate of responding to basal values, without showing any reinforcing properties when made contingent on nose-poking response. Our findings demonstrate that baclofen antagonises GHB i.v. self-administration, supporting an important role for the GABA(B) receptor in reward-related mechanisms underlying addictive behaviour.
γ-羟基丁酸（GHB）是一种广泛使用的消遣性药物，已知其在动物和人类中具有正向强化作用。GABA（B）受体激动剂巴氯芬已被证明具有抗动机作用，并能抑制酒精、可卡因、海洛因和尼古丁的摄入。在本研究中，我们评估了巴氯芬对初用药物小鼠静脉注射GHB自我给药的影响，给药方式为固定比率（FR-1）强化程序，并以类似戳鼻的反应作为操作行为。结果表明，巴氯芬能够完全阻止对GHB的觅药行为，将反应率降低至基础值，且当与戳鼻反应相关联时未表现出任何强化特性。我们的研究结果表明，巴氯芬可拮抗静脉注射GHB的自我给药，支持GABA（B）受体在成瘾行为相关奖励机制中发挥重要作用。
