Lath R, Chacko G, Chandy M J
Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, 632 004, India.
Neurol India. 2001 Jun;49(2):144-7.
Proliferative activity of 94 pituitary adenomas was assessed by the determination of the growth fraction, using MIB-1 monoclonal antibody in formalin fixed, paraffin embedded sections. This index was correlated with clinical and radiological evidence of invasiveness. The mean Ki-67 labeling index for all pituitary adenomas was 0.84% (range 0-17.45%). Hardy stage E tumours (1.44%) had a higher Ki-67 labeling index (LI) as compared with Hardy stage 0 tumours (0.36%). The difference in the Ki-67 labeling indices between invasive and non-invasive adenomas was not statistically significant. Hence, the Ki-67 labeling index is not a reliable indicator of invasiveness in pituitary adenomas.
采用MIB-1单克隆抗体，通过测定生长分数，在福尔马林固定、石蜡包埋切片中评估94例垂体腺瘤的增殖活性。该指标与侵袭性的临床和影像学证据相关。所有垂体腺瘤的平均Ki-67标记指数为0.84%（范围0-17.45%）。与Hardy 0期肿瘤（0.36%）相比，Hardy E期肿瘤（1.44%）的Ki-67标记指数（LI）更高。侵袭性和非侵袭性腺瘤之间的Ki-67标记指数差异无统计学意义。因此，Ki-67标记指数不是垂体腺瘤侵袭性的可靠指标。
