Cocks T M, Moffatt J D
Department of Pharmacology, The University of Melbourne, Victoria 3010, Australia.
Pulm Pharmacol Ther. 2001;14(3):183-91. doi: 10.1006/pupt.2001.0285.
Protease-activated receptors (PARs) act as sensors for active extracellular serine proteases. Since serine proteases like mast cell tryptase are associated with inflammatory processes, PARs may represent novel pharmacological targets in airway diseases like asthma and chronic obstructive pulmonary disease. However, our present understanding of the physiological roles of PARs is in its infancy. In this review we highlight evidence for the involvement of PARs in airway disease and propose that these novel receptors may play mainly protective roles.
蛋白酶激活受体（PARs）作为细胞外活性丝氨酸蛋白酶的传感器。由于诸如肥大细胞类胰蛋白酶等丝氨酸蛋白酶与炎症过程相关，PARs可能是哮喘和慢性阻塞性肺疾病等气道疾病中的新型药理学靶点。然而，我们目前对PARs生理作用的了解尚处于起步阶段。在本综述中，我们强调了PARs参与气道疾病的证据，并提出这些新型受体可能主要发挥保护作用。
