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膀胱内注射白细胞介素-2对复发性浅表性Ta-T1/G1-2期移行细胞膀胱癌的新辅助治疗

Neoadiuvant Treatment With Intravesical Interleukin-2 for Recurrent Superficial Transitional Bladder Carcinoma Ta-T1/G1-2.

作者信息

Grasso Marco, Torelli Fabrizio, Scannapieco Giuseppe, Franzoso Francesco, Lania Caterina

机构信息

Departments of Urology, Desio Hospital and San Raffaele Institute, Milan, Italy.

出版信息

J Immunother (1991). 2001 Mar;24(2):184-187.

PMID:11449075
Abstract

SUMMARY

The aim of this study was to evaluate the direct action of IL-2 on recurrent superficial transitional bladder carcinoma and the effect on recurrence rate. 27 patients were submitted to neoadjuvant treatment by intra-vesical instillation of recombinant IL-2 and to transurethral resection. We did not observe any effect on neoplasms but the recurrence rate was less than the expected one. It is possible that treatment of bladder carcinoma with intra-vesical instillation of IL-2 may promote immuno-prophilaxis.

摘要

摘要

本研究的目的是评估白细胞介素-2（IL-2）对复发性浅表性膀胱移行细胞癌的直接作用及其对复发率的影响。27例患者接受了经膀胱内灌注重组IL-2的新辅助治疗并接受了经尿道切除术。我们未观察到对肿瘤有任何作用，但复发率低于预期。膀胱内灌注IL-2治疗膀胱癌可能会促进免疫预防。

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