Steger J W, Izuno G T
Int J Dermatol. 1979 Jul-Aug;18(6):472-9. doi: 10.1111/j.1365-4362.1979.tb01953.x.
Zinc is an essential trace element whose malabsorption in early childhood may result in a skin disorder known as acrodermatitis enteropathica. Cutaneous lesions typical of acrodermatitis enteropathica have been described during total parenteral nutrition on zinc-deficient intravenous solutions in both adults and children. This condition has been named the "acute zinc depletion syndrome." A case is described in which a patient, despite a zinc intake of double the daily requirement, manifested the acute zinc depletion syndrome during therapy with combined liquid diet plus parenteral hyperalimentation. Predisposing factors in this individual included a short bowel syndrome and a large oral load of calcium lactate. Zinc metabolism is reviewed with attention to alterations in disease and during hyperalimentation. The clinical manifestations, predisposing factors, therapy and prevention of the acute zinc depletion syndrome are discussed.
锌是一种必需的微量元素，幼儿期锌吸收不良可能导致一种称为肠病性肢端皮炎的皮肤疾病。在成人和儿童中，使用缺锌的静脉溶液进行全胃肠外营养期间，均已出现肠病性肢端皮炎典型的皮肤病变。这种情况被称为“急性锌缺乏综合征”。本文描述了一例患者，尽管锌摄入量是每日需求量的两倍，但在联合流食加胃肠外高营养治疗期间仍表现出急性锌缺乏综合征。该个体的易感因素包括短肠综合征和大量口服乳酸钙。本文回顾了锌代谢，重点关注疾病和高营养期间的变化。讨论了急性锌缺乏综合征的临床表现、易感因素、治疗和预防。
