[大鼠海马体CA1区最小突触后电流中AMPA和NMDA成分的长期增强]

[Long-term potentiation of AMPA- and NMDA-components of minimal postsynaptic currents in CA1 area of the rat hippocampus].

作者信息

Baiazitov I T, Voronin L L, Kas'ianov A M, Kleshchevnikov A M, Kul'chitskiĭ S V, Sametskiĭ E A

机构信息

Institute of Brain Research, Russian Acad. Med. Sci., Per. Obukha, 5, 103064, Moscow, Russia.

出版信息

Ross Fiziol Zh Im I M Sechenova. 2001 Apr;87(4):448-58.

PMID:11449972

Abstract

Excitatory postsynaptic currents (EPSC) were recorded from pyramidal neurons of the rat hippocampal slices as well as the AMPA and NMDA components. A strong enough correlation between the amplitudes of the components provided a reliable evidence of their generation by the same synapse. Both components revealed similar LTP following afferent tetanisation. The data obtained do not support postsynaptic mechanisms of the LTP maintenance but suggest that increased presynaptic release represents a basic mechanism of the early LTP maintenance.

摘要

从大鼠海马切片的锥体神经元记录兴奋性突触后电流（EPSC）以及AMPA和NMDA成分。各成分幅度之间足够强的相关性为它们由同一突触产生提供了可靠证据。在传入性强直刺激后，两种成分均显示出相似的长时程增强（LTP）。所获得的数据不支持LTP维持的突触后机制，而是表明突触前释放增加是早期LTP维持的基本机制。