Agafonov A P, Strel'tsova M A, Susloparov I M, Ignat'ev G M
Vopr Virusol. 2001 May-Jun;46(3):30-3.
Immunosuppression was detected in six patients with parotitis. The proliferation of peripheral blood mononuclear cells, NK activity, and CD4/CD8 index decreased, while the production of tumor necrosis factor alpha and interleukin 1 beta increased on day 1 after clinical manifestation of mumps. The clinical diagnosis of mumps was confirmed by serological analysis of paired sera. Besides parotitis virus, herpes simplex type 1 virus was detected in two saliva samples by the polymerase chain reaction. Herpes (lip vesicles) manifested in these patients on days 8 and 11 after manifestation of parotitis.
在6例腮腺炎患者中检测到免疫抑制。在腮腺炎临床表现出现后的第1天，外周血单个核细胞增殖、NK活性及CD4/CD8指数下降，而肿瘤坏死因子α和白细胞介素1β的产生增加。腮腺炎的临床诊断通过双份血清的血清学分析得以证实。除了腮腺炎病毒外，通过聚合酶链反应在两份唾液样本中检测到1型单纯疱疹病毒。疱疹（唇部水疱）在这些患者腮腺炎出现后的第8天和第11天出现。
