Sipe E K, Trienski T L, Porter J M
Northeastern Ohio Universities College of Medicine, and St. Elizabeth Health Center, Youngstown, 44501, USA.
Am Surg. 2001 Jul;67(7):684-6.
Hypertension is a widespread entity in the surgical intensive care unit. Not only is the clinical spectrum varied, but the armamentarium available to the clinician is also wide-ranging. Sodium nitroprusside, a potent vasodilator with a short half-life, is often used for hypertensive crisis and to deliberately maintain a low blood in certain clinical conditions. Cyanide toxicity is a known complication of sodium nitroprusside use. Herein is reported a case of probable cyanide toxicity in an elderly trauma patient. The pharmacology of sodium nitroprusside and the pitfalls of making the diagnosis of cyanide toxicity are discussed.
高血压在外科重症监护病房中很常见。不仅临床表现多样,而且临床医生可用的治疗手段也多种多样。硝普钠是一种半衰期短的强效血管扩张剂,常用于治疗高血压危象,并在某些临床情况下刻意维持低血压。氰化物中毒是使用硝普钠已知的并发症。本文报道了一例老年创伤患者可能发生氰化物中毒的病例。文中讨论了硝普钠的药理作用以及氰化物中毒诊断中的陷阱。