Thomas Christopher, Svehla Lindsay, Moffett Brady S
Texas Children's Hospital, Department of Pharmacy, 6621 Fannin Street, MC 2-2510, Houston, TX 77030, USA.
Expert Opin Drug Saf. 2009 Sep;8(5):599-602. doi: 10.1517/14740330903081717.
Sodium nitroprusside (SNP) is often used as a continuous infusion intravenous vasodilator in pediatric patients. However, cyanide toxicity can occur with SNP therapy. Scant literature is available determining the safety of SNP therapy, the incidence of cyanide toxicity or the risk factors for cyanide toxicity in pediatric patients.
To review the literature concerning the safety of intravenous SNP with regard to cyanide toxicity in the pediatric patient population.
A MedLine search was used to identify articles pertaining to SNP therapy and cyanide toxicity in pediatric patients.
Sodium nitroprusside seems to be safe when used in critically ill pediatric patients. Cyanide toxicity may occur in patients with specific risk factors. Routine monitoring of cyanide levels may not be warranted.
硝普钠（SNP）常用于儿科患者的持续静脉输注血管扩张剂。然而，SNP治疗可能会发生氰化物中毒。关于SNP治疗的安全性、氰化物中毒的发生率或儿科患者氰化物中毒的危险因素，现有文献较少。
回顾有关儿科患者人群中静脉使用SNP与氰化物中毒安全性的文献。
使用医学文献数据库检索来识别与儿科患者SNP治疗和氰化物中毒相关的文章。
硝普钠在危重症儿科患者中使用似乎是安全的。特定危险因素的患者可能会发生氰化物中毒。可能无需常规监测氰化物水平。
