Frachon S, Gouysse G, Dumortier J, Couvelard A, Nejjari M, Mion F, Berger F, Paliard P, Boillot O, Scoazec J Y
Service Central d'Anatomie et Cytologie Pathologiques, Hĵpital Edouard Herriot Lyon, France.
J Hepatol. 2001 Jun;34(6):850-7. doi: 10.1016/s0168-8278(01)00049-6.
BACKGROUNDS/AIMS: Hepatocellular carcinoma usually contains continuous capillary vessels lacking the differentiation markers specific for normal sinusoidal endothelial cells. We therefore aimed to search for alterations in endothelial cell marker expression in precancerous liver lesions.
Expression of the endothelial cell markers CD31, CD34 and BNH9 was analyzed in 138 dysplastic lesions from 40 cirrhotic patients (20 with and 20 without hepatocellular carcinoma).
No expression of the three endothelial cell markers was detected in cirrhotic nodules and in non dysplastic regenerative macronodules. The three markers were detected in 29.8% of dysplastic lesions and 47% of hepatocellular carcinomas. At least one marker was detected in 75% of dysplastic lesions and 100% of hepatocellular carcinomas. The three markers were more frequently expressed in areas of small cell than of large cell change (34 vs 10%). No correlation was found with the grade of dysplasia, the occurrence of arterialization and the association with hepatocellular carcinoma.
Alterations in the hepatic microcirculation comparable to those observed in hepatocellular carcinoma are present in a significant proportion of dysplastic lesions of the liver and may be indirect markers of the process of liver carcinogenesis.
背景/目的：肝细胞癌通常含有连续性毛细血管，缺乏正常肝血窦内皮细胞特有的分化标志物。因此，我们旨在探寻癌前肝损伤中内皮细胞标志物表达的变化。
分析了40例肝硬化患者（20例伴有肝细胞癌，20例不伴有肝细胞癌）的138个发育异常病变中内皮细胞标志物CD31、CD34和BNH9的表达情况。
在肝硬化结节和非发育异常的再生大结节中未检测到这三种内皮细胞标志物的表达。在29.8%的发育异常病变和47%的肝细胞癌中检测到这三种标志物。在75%的发育异常病变和100%的肝细胞癌中检测到至少一种标志物。这三种标志物在小细胞改变区域比大细胞改变区域更频繁表达（34%对10%）。未发现与发育异常等级、动脉化发生情况及与肝细胞癌的关联存在相关性。
相当一部分肝脏发育异常病变中存在与肝细胞癌中观察到的类似的肝微循环改变，可能是肝癌发生过程的间接标志物。
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