从肺炎克雷伯菌临床分离株中鉴定出一种编码SHV-12、TEM-1和IMP-2金属β-内酰胺酶变体IMP-8的质粒。
Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae.
作者信息
Yan J J, Ko W C, Wu J J
机构信息
Department of Pathology, National Cheng Kung University Medical Center, Tainan, Taiwan.
出版信息
Antimicrob Agents Chemother. 2001 Aug;45(8):2368-71. doi: 10.1128/AAC.45.8.2368-2371.2001.
Abstract
A multidrug-resistant plasmid encoding TEM-1, SHV-12, and a variant of IMP-2 metallo-beta-lactamase, designated IMP-8, was identified from a clinical isolate of Klebsiella pneumoniae. There are four nucleotide differences between bla(IMP-2) and bla(IMP-8), resulting in two amino acid differences. bla(IMP-8) was also found to be carried by an integron-borne gene cassette similar to the bla(IMP-2) cassette.
摘要
从肺炎克雷伯菌的临床分离株中鉴定出一种携带TEM-1、SHV-12和IMP-2金属β-内酰胺酶变体（命名为IMP-8）的多重耐药质粒。bla(IMP-2)和bla(IMP-8)之间存在四个核苷酸差异，导致两个氨基酸差异。还发现bla(IMP-8)由一个与bla(IMP-2)基因盒相似的整合子携带的基因盒携带。
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