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本文引用的文献

1
Amino acid substitutions in a variant of IMP-1 metallo-beta-lactamase.IMP-1金属β-内酰胺酶变体中的氨基酸替换
Antimicrob Agents Chemother. 2000 Aug;44(8):2023-7. doi: 10.1128/AAC.44.8.2023-2027.2000.
2
Prevalence of SHV-12 among clinical isolates of Klebsiella pneumoniae producing extended-spectrum beta-lactamases and identification of a novel AmpC enzyme (CMY-8) in Southern Taiwan.台湾南部产超广谱β-内酰胺酶肺炎克雷伯菌临床分离株中SHV-12的流行情况及一种新型AmpC酶（CMY-8）的鉴定
Antimicrob Agents Chemother. 2000 Jun;44(6):1438-42. doi: 10.1128/AAC.44.6.1438-1442.2000.
3
Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of bla(IMP) allelic variants carried by gene cassettes of different phylogeny.鲍曼不动杆菌AC-54/97金属β-内酰胺酶决定簇的特征分析揭示了不同系统发育的基因盒所携带的bla(IMP)等位基因变体的存在。
Antimicrob Agents Chemother. 2000 May;44(5):1229-35. doi: 10.1128/AAC.44.5.1229-1235.2000.
4
Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.VIM-2的特性研究，VIM-2是一种可水解碳青霉烯类的金属β-内酰胺酶及其来自法国一株铜绿假单胞菌临床分离株的质粒和整合子携带基因。
Antimicrob Agents Chemother. 2000 Apr;44(4):891-7. doi: 10.1128/AAC.44.4.891-897.2000.
5
Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate.blaVIM的克隆与特性分析，blaVIM是一种来自铜绿假单胞菌临床分离株的新型整合子携带的金属β-内酰胺酶基因。
Antimicrob Agents Chemother. 1999 Jul;43(7):1584-90. doi: 10.1128/AAC.43.7.1584.
6
Rapid detection and evaluation of clinical characteristics of emerging multiple-drug-resistant gram-negative rods carrying the metallo-beta-lactamase gene blaIMP.携带金属β-内酰胺酶基因blaIMP的新型多重耐药革兰阴性杆菌临床特征的快速检测与评估
Antimicrob Agents Chemother. 1998 Aug;42(8):2006-11. doi: 10.1128/AAC.42.8.2006.
7
PCR detection of metallo-beta-lactamase gene (blaIMP) in gram-negative rods resistant to broad-spectrum beta-lactams.对耐广谱β-内酰胺类的革兰氏阴性杆菌进行金属β-内酰胺酶基因（blaIMP）的聚合酶链反应检测
J Clin Microbiol. 1996 Dec;34(12):2909-13. doi: 10.1128/jcm.34.12.2909-2913.1996.
8
Multifocal outbreaks of metallo-beta-lactamase-producing Pseudomonas aeruginosa resistant to broad-spectrum beta-lactams, including carbapenems.对包括碳青霉烯类在内的广谱β-内酰胺耐药的产金属β-内酰胺酶铜绿假单胞菌的多灶性暴发。
Antimicrob Agents Chemother. 1996 Feb;40(2):349-53. doi: 10.1128/AAC.40.2.349.
9
beta-Lactamases in laboratory and clinical resistance.实验室及临床耐药中的β-内酰胺酶
Clin Microbiol Rev. 1995 Oct;8(4):557-84. doi: 10.1128/CMR.8.4.557.
10
Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance.在一株表现出亚胺培南耐药性的粘质沙雷氏菌临床分离株中发现的一种肠杆菌金属β-内酰胺酶的分子特征。
Antimicrob Agents Chemother. 1994 Jan;38(1):71-8. doi: 10.1128/AAC.38.1.71.

从肺炎克雷伯菌临床分离株中鉴定出一种编码SHV-12、TEM-1和IMP-2金属β-内酰胺酶变体IMP-8的质粒。

Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae.

作者信息

Yan J J, Ko W C, Wu J J

机构信息

Department of Pathology, National Cheng Kung University Medical Center, Tainan, Taiwan.

出版信息

Antimicrob Agents Chemother. 2001 Aug;45(8):2368-71. doi: 10.1128/AAC.45.8.2368-2371.2001.

DOI:10.1128/AAC.45.8.2368-2371.2001
PMID:11451699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC90656/
Abstract

A multidrug-resistant plasmid encoding TEM-1, SHV-12, and a variant of IMP-2 metallo-beta-lactamase, designated IMP-8, was identified from a clinical isolate of Klebsiella pneumoniae. There are four nucleotide differences between bla(IMP-2) and bla(IMP-8), resulting in two amino acid differences. bla(IMP-8) was also found to be carried by an integron-borne gene cassette similar to the bla(IMP-2) cassette.

摘要

从肺炎克雷伯菌的临床分离株中鉴定出一种携带TEM-1、SHV-12和IMP-2金属β-内酰胺酶变体（命名为IMP-8）的多重耐药质粒。bla(IMP-2)和bla(IMP-8)之间存在四个核苷酸差异，导致两个氨基酸差异。还发现bla(IMP-8)由一个与bla(IMP-2)基因盒相似的整合子携带的基因盒携带。